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An active-site inhibitor of the catalytic activity of c-Met kinase (Ki = 4 nM; IC50 = 9 nM) that exhibits >50-fold selectivity for c-Met over a panel of tyrosine and serine-threonine kinases; inhibits c-Met phosphorylation, as well as cell proliferation and cell motility, of various tumor cells (IC50s = 18-50 nM)
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