Valinomycin is a potassium-specific ionophore and cyclic dodecadepsi-peptide antibiotic. Its complex with potassium disrupts the normal K+ gradient across biological bilayer membranes, leading to cell death. This property contributes to its antibiotic, antifungal, antiviral, antitumor, and insecticidal efficacy. Incorporating Valinomycin into liposomes can reduce cytotoxicity and enhance targeting, making it a valuable research tool.
- Potassium-specific ionophore
- Disrupts normal K+ gradient across cell membranes
- Exhibits antibiotic, antifungal, antiviral, antitumor, and insecticidal efficacy
- Can be incorporated into liposomes to reduce cytotoxicity and enhance targeting
- Cyclic dodecadepsi-peptide structure
- Storage Conditions:
- Powder: -80°C for 2 years; -20°C for 1 year (sealed storage, away from moisture)
- In solvent: -80°C for 6 months; -20°C for 1 month (sealed storage, away from moisture)