CAS RN 439575-02-7
CAS RN 439575-02-7
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MilliporeSigma™ Calbiochem™ ITK Inhibitor, BMS-509744
A cell-permeable aminothioaryl-thiazolo compound that potently inhibits ITK kinase activity (IC50 = 19nM; [ATP] = 1μM) in an ATP-competitive manner by stabilizing ITK activation loop in a substrate-blocking, inactive conformation, inhibiting Fyn, IR, Lck, Btk only at much higher concentrations (IC50