Thermo Scientific Small Molecules for Drug Discovery
- Bioactives
- High-Throughput Screening
- Fragment Screening
- Monomers
- Chemical Probes
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Bioactive Small Molecules
Small molecules are integral to the drug development process, aiding in everything from target discovery and mechanistic exploration to lead refinement, preclinical assessment, and translational studies. Because of their flexibility, they are key components in both hypothesis-based research and phenotypic screening.
For every stage of your workflow, you can trust the Thermo Scientific™ Small Molecule Collection, from exploration to using assays to probe pathways or disease mechanisms. Choose from a wide selection of bioactive molecules, antibiotics, signal transduction molecules, and more to advance your work.
By selecting from smaller, curated assortments of molecular compounds with known bioactivity or target relevance, you can improve your ability to collect high-impact data and make quicker decisions—ultimately minimizing false positives, improving translational outcomes, and reducing costs.
Bioactive Research Tools
Explore bioactives and antibiotics to accelerate discovery and improve data confidence.
Key Features
Benefits
- Enhance your research with a curated portfolio of bioactive compounds, antibiotics, and signal transduction molecules—supporting high-throughput screening, target validation, and pathway analysis across key therapeutic areas
- Unlock your workflow with compounds designed to modulate cellular targets and signaling pathways. Optimized for real-world drug properties, they help enable more targeted research than traditional hit-like collections.
- Achieve reliable, reproducible results with premium, experimentally validated molecules—ideal for in vitro, cell-based, and early in vivo studies across diverse research applications
- Help elevate your data quality while reducing complexity and costs
- Enhance your early- and mid-stage investigation with small molecules featuring validated bioactivity and drug-like properties
- Accelerate your progress from target engagement to lead optimization and support diverse therapeutic research applications
- Advance your workflow from basic biology to preclinical development with molecules designed to support studies of cancer, heart disease, infections, and brain disorders
High-Throughput Screening
Maximize your drug discovery success with screening libraries designed to increase the odds of positive results while optimizing cost, time, and effort spent per project.
The Maybridge screening collection, a critical tool in screening campaigns, contains over 53,000 structurally and functionally diverse organic compounds. These compounds demonstrate suitable pharmacokinetic properties and exclude potentially problematic structures, helping to enhance outcomes for your program.
Manufactured by Thermo Fisher Scientific using innovative synthetic techniques and backed by over 45 years of experience in heterocyclic chemistry, Maybridge screening libraries provide the reliability you need.
Ready to Learn More?
Contact us today to learn more about how the Fisher Scientific channel can streamline your high-throughput screening workflow.
Choose the Maybridge screening collection to make your drug discovery program
Key Features
Benefits
- The Maybridge Screening Collection is a highly diverse set of over 53,000 hit-like and lead-like molecules widely acknowledged as a critical tool in screening campaigns
- The compounds comply with the classic characteristics of drug-like molecules, as defined by Lipinski’s rule of 5. These rules are essentially a pragmatic reduction of the common features of the drugs represented by the World Drug Index
- Libraries are comprised of compounds with the right chemical properties for successful hit finding
- A smaller but highly diverse screening collection will provide a greater hit probability than larger, less diverse libraries
- Screening compounds that have the right chemical properties are more likely to achieve successful results faster and at a lower cost
- Can accelerate your discovery campaigns by giving you a reliable starting point for hit-to-lead optimization
Fragment Screening
Count on the Maybridge fragment library for your fragment-based drug screening. The library features 2,500 chemical fragments and is an industry leader due to its diversity, novelty, and pharmacophoric content.
In drug discovery, fragment screening has emerged as a preferred technique for quickly identifying new lead molecules. This approach offers a higher likelihood of success and requires screening fewer fragments.
Ready to Learn More?
Contact us today about upgrading your fragment-based drug screening with the Maybridge fragment library.
Key Features
Benefits
- Maybridge fragment libraries contain structurally diverse compounds, improving your chances of finding “hits”
- Solubility in phosphate-buffered saline (PBS buffer) makes the fragments in the library suitable for whatever technique you are reusing to screen
- The fragments in the library have been pre-screened for surface plasmon resonance (SPR) to help ensure they are compatible with your instruments
- Compounds with a history of providing false hits are removed so you can be sure yours are genuine
- Enables the delivery of acceptable absorption, distribution, metabolism, and excretion (ADME) attributes
- Based on standard Daylight fingerprints, the compounds in the library overlap by 66%, according to the Tanimoto similarity index, which indicates a moderate degree of similarity
- Pan assay interference compounds (PAINS) have been removed from the library to help you avoid false hits
- Helps ensure the availability of robust screening data and minimizes candidate attrition through experimentally measured solubility of fragments in PBS buffer (1 mM)
- In collaboration with Cytiva Healthcare specialists and using a Biacore™ SPR instrument, a Clean Screen was run to remove promiscuous binders from the library
Hit-to-Lead Optimization Monomers
Enhancing the availability of a wide array of synthetic building blocks that are pharmacophorically relevant is essential for successful drug design. When crucial building blocks are not readily available on the market, synthesizing them internally can be time-consuming and significantly increase project costs.
Medicinal chemists rely on access to optimal building blocks for early-stage drug discovery, specifically for:
- Developing structure-activity relationships (SAR)
- Creating screening libraries to identify and elaborate on hits
Explore a broad selection of medicinally pertinent building blocks and monomers crafted to enhance lead optimization through structure-activity relationship (SAR) development.
Monomers and Building Blocks
Access a broad selection of monomers and building blocks to support compound synthesis and library development.
Key Features
Benefits
- Enhance the pharmacophoric characteristics of your lead compounds
- Support a wide range of chemical synthesis methodologies
- Allow comprehensive investigation of structural diversity
- Simplify the analysis of SAR
- Over 25,000 monomers are available with over 300 different heterocyclic ring systems
- Support all synthetically useful functional groups
- Accommodate all functionally significant synthetic groups
- You can view all possible ring regioisomers
- Compounds feature minimal extra substitution
Chemical Probes
Vital in both academic and pharmaceutical research and development, Thermo Scientific™ chemical probes are selective small molecules that modulate protein function, allowing you to explore mechanistic and phenotypic aspects of your molecular targets in cellular or animal studies.
Chemical probes help mitigate technical and biological risks associated with targeting a pathway or protein before committing to the extensive process of drug development and clinical trials. They play a crucial role in validating new molecular targets for therapeutic purposes.
Learn More About Thermo Scientific Chemical Probes
Browse a selection of products designed for specificity and reliable performance.
Key Features
Benefits
- Enable confirmation of the Mode of Action (MoA) of your drug candidates
- Reduce the likelihood of unforeseen side effects during clinical trials
- Increase the chances of successfully completing your drug discovery program
- Biological attributes include a defined MoA, high selectivity, high in vitro potency, and on-target effects demonstrated in cellular studies
- Physicochemical characteristics encompass solubility, stability, membrane permeability, and a well-characterized, reproducible structure
- Compounds with pan-assay interference (PAINS) properties are excluded to avoid issues such as covalent reactivity, redox activity, and colloidal aggregation
Contact Us
Enhance your ability to collect high-impact data and make quicker drug development decisions with the Thermo Scientific™ Small Molecule Collection.
If you need help finding specific products or want to learn more about the Maybridge Screening Collection or Maybridge Fragment Libraries, our experts are ready to provide assistance.
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