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Medchemexpress LLC 1,1,1,3,3,3-hexafluoropropan-2-yl 4-(3-phenoxybenzyl)piperazine-1-carboxylate | 1416133-89-5 | MFCD22987956 | 99.9% | 462.39 | C21H20F6N2O3 | 50MG
SDP

Supplier:  Medchemexpress LLC HY1233250MG

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JW-642 is a research-grade, selective inhibitor of monoacylglycerol lipase (MAGL) used to probe endocannabinoid signaling and lipid metabolism. It provides low-nanomolar potency against MAGL across species while showing much weaker activity against fatty acid amide hydrolase, supporting its use as a selective pharmacological tool.

  • Potent MAGL inhibition in human, mouse, and rat (IC50: 3.7 nM human; 7.6 nM mouse; 14 nM rat).
  • Reduced activity versus FAAH (micromolar IC50s), indicating selectivity.
  • High purity (99.9% by HPLC) for consistent experimental performance.
  • Solid, stable material suitable for analytical and preparative applications.
  • Recommended storage under nitrogen at 4°C; in solution store at -80°C for long-term stability.
  • Suitable for biochemical, enzymatic, and cell-based assays.

Catalog No. 50-002-39030


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