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Medchemexpress LLC 1,3(2H,4H)-Isoquinolinedione, 4-[(1-methyl-1H-pyrrol-2-yl)methylene]- | 1104546-89-5 | 99.89% | 252.27 | 1 ML
SDP

Catalog No. 5000344904
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BYK204165 is a potent and selective PARP1 inhibitor. It inhibits cell-free recombinant human PARP-1 (hPARP-1) with a pIC50 of 7.35 (pKi=7.05) and murine PARP-2 (mPARP-2) with a pIC50 of 5.38. It displays 100-fold selectivity for PARP-1. In kinetic experiments with human PARP-1, it exhibits potent and competitive inhibition of enzyme activity, yielding a pKi value of 7.05.

  • Exhibits low potency of PARP inhibition in C4I cells (pIC50 of 5.75).
  • Not investigated in vivo due to its short half-time (t1/2) of 23 min measured at rat microsomes in vitro.

Catalog No. 50-003-44904 Supplier Medchemexpress LLC Supplier No. HY10863210MG
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BYK204165 is a potent and selective PARP1 inhibitor. It inhibits cell-free recombinant human PARP-1 (hPARP-1) with a pIC50 of 7.35 (pKi=7.05) and murine PARP-2 (mPARP-2) with a pIC50 of 5.38. It displays 100-fold selectivity for PARP-1. In kinetic experiments with human PARP-1, it exhibits potent and competitive inhibition of enzyme activity, yielding a pKi value of 7.05.

  • Exhibits low potency of PARP inhibition in C4I cells (pIC50 of 5.75).
  • Not investigated in vivo due to its short half-time (t1/2) of 23 min measured at rat microsomes in vitro.

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