Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 5000344904

Medchemexpress LLC 1,3(2H,4H)-Isoquinolinedione, 4-[(1-methyl-1H-pyrrol-2-yl)methylene]- | 1104546-89-5 | 99.89% | 252.27 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY10863210MG

Encompass_Preferred

BYK204165 is a potent and selective PARP1 inhibitor. It inhibits cell-free recombinant human PARP-1 (hPARP-1) with a pIC50 of 7.35 (pKi=7.05) and murine PARP-2 (mPARP-2) with a pIC50 of 5.38. It displays 100-fold selectivity for PARP-1. In kinetic experiments with human PARP-1, it exhibits potent and competitive inhibition of enzyme activity, yielding a pKi value of 7.05.

  • Exhibits low potency of PARP inhibition in C4I cells (pIC50 of 5.75).
  • Not investigated in vivo due to its short half-time (t1/2) of 23 min measured at rat microsomes in vitro.

Catalog No. 50-003-44904


May include imposed supplier surcharges.
Only null left
Add to Cart

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.