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Medchemexpress LLC 1-[(3,5-dichlorophenyl)sulfonyl]-N-[(4-fluorophenyl)methyl]-4-piperidinecarboxamide | 2227549-00-8 | >98.0% | 445.34 Da | C19H19Cl2FN2O3S | 50MG
SDP

Supplier:  Medchemexpress LLC HY12473850MG

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A small-molecule chemical probe that potently and selectively inhibits the sodium-coupled citrate transporter SLC13A5 (NaCT). It is reported to act as a high-affinity, selective, and functionally irreversible inhibitor in human cells and is used as a research tool to study citrate transport and liver metabolism.

  • Potent, selective inhibition of human SLC13A5 (IC50 = 56 nM in HEK cells; 24 nM in HepG2 cells).
  • High selectivity over other SLC13 family members (IC50 > 100 μM).
  • Chemical formula C19H19Cl2FN2O3S and molecular weight 445.34 Da.
  • Purity ≥98.0% (HPLC).
  • Low aqueous solubility (<1 μg/mL at pH 6.8); soluble in DMSO.
  • High plasma protein binding in human plasma (~99%).
  • Moderate microsomal stability and variable hepatocyte stability across species.

Catalog No. 50-002-35473


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