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Medchemexpress LLC 1-(3,5-dichlorophenyl)sulfonyl piperidin-4-yl (4-fluorophenyl)methylamino methanone | 2227549-00-8 | 99.3% | 444.0 g/mol | C19H19Cl2FN2O3S | 25MG
SDP

Supplier:  Medchemexpress LLC HY12473825MG

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BI01383298 is a chemical probe that potently and selectively inhibits the human sodium-citrate co-transporter SLC13A5 (NaCT). It exhibits low-nanomolar cellular potency and high selectivity, making it suitable for in vitro functional and mechanistic studies of citrate transport in human cells. Note: the compound shows no activity at mouse SLC13A5 and is therefore not recommended for mouse model studies.

  • Potent inhibitor of human SLC13A5 with low-nanomolar cellular potency.
  • High selectivity (>1,000-fold) over closely related transporters.
  • Validated in HEK cells overexpressing SLC13A5 and HepG2 cells with endogenous expression.
  • Irreversible, non-competitive inhibition mechanism useful for mechanistic studies.
  • No activity against mouse SLC13A5; avoid mouse in vivo use.
  • Reported high chemical purity suitable for research applications.

Catalog No. 50-002-36076


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