1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane, 97%

Description

CAS: 69304-37-6 | C12H28Cl2OSi2 | 315.425 g/mol

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane is a silylating reagent used for simultaneous protection of 3'- and 5'-hydroxy functions of ribonucleosides. It is used in the analysis of Watson-Crick and Hoogstein base pairing in nucleotides. It is also employed in the formation of ribavirin chemical delivery systems. Further, it serves as a protecting group reagent for open-chain polyhydroxy compounds. In addition to this, it is involved in the preparation of cyclic bridged peptides.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane is a silylating reagent used for simultaneous protection of 3′- and 5′-hydroxy functions of ribonucleosides. It is used in the analysis of Watson-Crick and Hoogstein base pairing in nucleotides. It is also employed in the formation of ribavirin chemical delivery systems. Further, it serves as a protecting group reagent for open-chain polyhydroxy compounds. In addition to this, it is involved in the preparation of cyclic bridged peptides.

Solubility
Miscible with dimethylformamide, hexane, ethyl acetate, chloroform and dichloromethane.

Notes
Incompatible with strong oxidizing agents and water.

Specifications

Chemical Identifiers

• CAS: 69304-37-6
• Molecular Formula: C12H28Cl2OSi2
• Molecular Weight (g/mol): 315.425
• MDL Number: MFCD00009655
• InChI Key: DDYAZDRFUVZBMM-UHFFFAOYSA-N
• Synonym: 1,3-dichloro-1,1,3,3-tetraisopropyldisiloxane, 1,3-dichlorotetraisopropyldisiloxane, 1,1,3,3-tetraisopropyl-1,3-dichlorodisiloxane, 1,3-dichloro-1,1,3,3-tetraisopropyl-disiloxane, disiloxane, 1,3-dichloro-1,1,3,3-tetrakis 1-methylethyl, 1,1,3,3-tetraisopropyl-1,3-dichlorosiloxane, chloro chlorodiisopropylsilyl oxy diisopropylsilane, chloro-chloro-di propan-2-yl silyl oxy-di propan-2-yl silane, tipdsicl2, tipdsi-cl2
• PubChem CID: 172404
• IUPAC Name: chloro-[chloro-di(propan-2-yl)silyl]oxy-di(propan-2-yl)silane
• SMILES: CC(C)[Si](C(C)C)(O[Si](C(C)C)(C(C)C)Cl)Cl

• Boiling Point: 69°C to 70°C (0.5mmHg)
• Quantity: 25 g
• UN Number: UN1760
• Beilstein: 1934216
• Flash Point: >110°C (230°F)
• Solubility Information: Miscible with dimethylformamide,hexane,ethyl acetate,chloroform and dichloromethane.
• Formula Weight: 315.43
• Percent Purity: 97%
• Refractive Index: 1.454
• Sensitivity: Moisture sensitive
• Density: 0.986
• Chemical Name or Material: 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

Safety and Handling

Hazard Category	H227-H314
Hazard Statement	GHS H Statement H314-H318 Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statement	P210-P260-P264b-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P374-P501c
DOTInformation	Transport Hazard Class: 8; Packing Group: II; Proper Shipping Name: CORROSIVE LIQUIDS, N.O.S.
EINECSNumber	000-000-0
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only