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Sigma Aldrich 1,3-Dimethyl-3,4,5,6-Tetrahydro-2(1H)-Pyrimidinone

Catalog No. 41661250ML Shop All MilliporeSigma Sigma Organic Chemistry Products
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41-661-250ML 250 mL
41-661-1L 1 L
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MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone (DMPU) can be used as a:Solvent in the synthesis of 1-aryl-3,4,5-substituted pyrazoles by cyclocondensation of 1,3-diketones with arylhydrazine hydrochlorides.Chelating solvent in the trifluoromethylation of activated and non-activated halogenated double bonds.Ligand in ortho-alkylation of secondary benzamide catalyzed by cobalt.Aprotic, dipolar solvent, which is an excellent replacement of the carcinogenic HMPA as cosolvent for highly reactive nucleophiles and bases. High Z-selectivity in enolate formation; DMPU was shown to be non-mutagenic and safe.

Specifications

CAS 7226-23-5
Density 1.06 g/mL at 25°C
Boiling Point 146°C (44 mmHg, lit.)
Molecular Formula C6H12N2O
Linear Formula C6H12N2O
Refractive Index n20/D 1.488; n20/D 1.489
MDL Number MFCD00006550
Quantity 250 mL
Synonym 1,3-Dimethyl-2-oxohexahydropyrimidine; N,N'-Dimethylpropylene urea; DMPU
Molecular Weight (g/mol) 128.17 g/mol
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