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Medchemexpress LLC 1,4-Benzenedicarboxylic acid | 100-21-0 | 99.9% | 166.13 | 10 G
Supplier: Medchemexpress LLC HYW01009810G
Terephthalic acid is an isomer and a precursor of polyester PET, which can be used to make clothing and plastics. It can also be utilized to build skin tumor models.
- Can be used in animal modeling to create skin tumor models.
- It is metabolized in the body to form calcium terephthalate or calcium hydrogen terephthalate, which can lead to bladder stone formation.
- The lithogenic effect is more pronounced in weanling mice at higher doses.
- Promotes excessive cell proliferation and induces skin tumor formation by disrupting the p16-cyclin D1/Cdk4-Rb cell cycle regulatory pathway.
- Specific modeling methods for skin tumor induction involve topical application in C57BL/6 mice.
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