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Medchemexpress LLC 1-[4-chloro-2-hydroxy-3-(3S-methyloxolan-3-yl)sulfonylphenyl]-3-(1R-2-methylcyclopentenyl)urea | 1838123-21-9 | 99.5% | 25 MG
SDP

Catalog No. 5000230720
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CXCR2-IN-2 is a selective, brain-penetrant, orally bioavailable antagonist of the chemokine receptor CXCR2 used in preclinical pharmacology to probe CXCR2-mediated signaling and inflammatory responses. It demonstrates low-nanomolar potency in cell-based assays and high selectivity over related chemokine receptors.

  • Selective, brain-penetrant CXCR2 antagonist.
  • Low-nanomolar potency (IC50 5.2 nM in β-arrestin assay; 1 nM in CXCR2 Tango assay).
  • Inhibits Gro-α-induced CD11b expression in human whole blood (IC50 0.04 μM).
  • High selectivity versus CXCR1 and other chemokine receptors.
  • High purity (≈99.5%) and white to off-white solid appearance.
  • Soluble in DMSO (240 mg/mL); store powder at -20°C for long-term stability.
  • Offered as a 25 MG solid package suitable for preclinical studies.

Catalog No. 50-002-30720 Supplier Medchemexpress LLC Supplier No. HY12087825MG
May include imposed supplier surcharges.
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CXCR2-IN-2 is a selective, brain-penetrant, orally bioavailable antagonist of the chemokine receptor CXCR2 used in preclinical pharmacology to probe CXCR2-mediated signaling and inflammatory responses. It demonstrates low-nanomolar potency in cell-based assays and high selectivity over related chemokine receptors.

  • Selective, brain-penetrant CXCR2 antagonist.
  • Low-nanomolar potency (IC50 5.2 nM in β-arrestin assay; 1 nM in CXCR2 Tango assay).
  • Inhibits Gro-α-induced CD11b expression in human whole blood (IC50 0.04 μM).
  • High selectivity versus CXCR1 and other chemokine receptors.
  • High purity (≈99.5%) and white to off-white solid appearance.
  • Soluble in DMSO (240 mg/mL); store powder at -20°C for long-term stability.
  • Offered as a 25 MG solid package suitable for preclinical studies.

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