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Medchemexpress LLC 1-[(4-tert-butylphenyl)methyl]-3-[[3-fluoro-4-(methanesulfonamido)phenyl]methyl]thiourea | 401907-26-4 | MFCD29770787 | 99.5% | 423.57 g/mol | C20H26FN3O2S2 | 5 MG
SDP

Supplier:  Medchemexpress LLC HY1006685MG

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JYL 1421 is a potent transient receptor potential vanilloid 1 (TRPV1) antagonist used in preclinical research. It inhibits capsaicin-evoked intracellular Ca2+ accumulation in vitro (IC50 = 8 nM) and reduces capsaicin-induced behaviors in rodents (ID50 ≈ 4.6 mg/kg, i.p.). Supplied as a high-purity solid and as DMSO stock solutions for pharmacology and biochemical assays.

  • Potent TRPV1 inhibition (IC50 = 8 nM).
  • Blocks capsaicin-evoked Ca2+ accumulation in vitro.
  • Demonstrated in vivo activity in rodent models (ID50 ≈ 4.6 mg/kg, i.p.).
  • High purity suitable for research (>99%).
  • Available as solid and as DMSO solution for convenient dosing.

Catalog No. 50-002-13556


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