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Medchemexpress LLC 1-Dodecylimidazole | 4303-67-7 | 99.8% | 236.40 | 500 MG
SDP

Catalog No. 5000349882
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1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and cytotoxic agent that induces cell death by acid-dependent accumulation in lysosomes, followed by disruption of the lysosomal membrane and release of cysteine proteases into the cytoplasm. It also displays hypocholesterolaemic and broad-spectrum antifungal activities. In vitro studies show its cytotoxicity is pH-dependent, with significantly greater cell killing at pHe 6.0 than at pHe 7.0. In vivo, its hypocholesterolaemic effect is partly due to the inhibition of cholesterol biosynthesis.

  • Lysosomotropic detergent
  • Cytotoxic agent
  • Induces cell death via lysosomal membrane disruption and cysteine protease release
  • Exhibits hypocholesterolaemic activity
  • Possesses broad-spectrum antifungal activities
  • Shows pH-dependent cytotoxicity in vitro
  • Inhibits cholesterol biosynthesis in vivo

Catalog No. 50-003-49882 Supplier Medchemexpress LLC Supplier No. HY138540500MG
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1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and cytotoxic agent that induces cell death by acid-dependent accumulation in lysosomes, followed by disruption of the lysosomal membrane and release of cysteine proteases into the cytoplasm. It also displays hypocholesterolaemic and broad-spectrum antifungal activities. In vitro studies show its cytotoxicity is pH-dependent, with significantly greater cell killing at pHe 6.0 than at pHe 7.0. In vivo, its hypocholesterolaemic effect is partly due to the inhibition of cholesterol biosynthesis.

  • Lysosomotropic detergent
  • Cytotoxic agent
  • Induces cell death via lysosomal membrane disruption and cysteine protease release
  • Exhibits hypocholesterolaemic activity
  • Possesses broad-spectrum antifungal activities
  • Shows pH-dependent cytotoxicity in vitro
  • Inhibits cholesterol biosynthesis in vivo

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