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Medchemexpress LLC 1-Hexadecanaminium, N-[2-[[(4-methoxyphenyl)methyl]-2-pyrimidinylamino]ethyl]-N,N-dimethyl-, bromide (1:1) | 553-08-2 | 99.9% | 100 MG
SDP

Supplier:  Medchemexpress LLC HYB1246100MG

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Thonzonium bromide is an antibacterial agent and a monocationic surface-active agent. It inhibits RANKL-induced osteoclast formation and bone resorption in vitro, and prevents LPS-induced bone loss in vivo. This compound also inhibits proton transport in a dose-dependent manner (EC50=69 μM).

  • Antibacterial agent.
  • Monocationic surface-active agent.
  • Inhibits RANKL-induced osteoclast formation and bone resorption in vitro.
  • Prevents LPS-induced bone loss in vivo.
  • Inhibits proton transport in a dose-dependent manner (EC50=69 μM).
  • Blocks RANKL-induced activation of NF-κB, ERK, and c-Fos, as well as NFATc1 induction.
  • Disrupts F-actin ring formation, causing disturbances in cytoskeletal structure in mature osteoclasts during bone resorption.
  • Exhibits protective effects in an in vivo murine model of LPS-induced calvarial osteolysis.

Catalog No. 50-004-12988


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