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Medchemexpress LLC 1-Hydroxypyrene | 5315-79-7 | 99.84% | 218.25 | 500 MG
Supplier: Medchemexpress LLC 500MGHYW014075
1-Hydroxypyrene is a widely recognized biomarker for exposure to polycyclic aromatic hydrocarbons (PAHs), primarily analyzed in urine samples. It serves as the main biomarker for pyrenes exposure and functions as an orally active agonist for the aryl hydrocarbon receptor (AhR), which can contribute to renal fibrosis.
- Biomarker for polycyclic aromatic hydrocarbon (PAH) exposure
- Major biomarker for pyrenes exposure
- Orally active agonist for the aryl hydrocarbon receptor (AhR)
- Contributes to renal fibrosis
- Inhibits cell viability in HK-2 cells
- Increases expression of AhR, Cyp1a1/Cyp1a2/Cyp1b1, collagen I, α-smooth muscle actin (α-SMA), and fibronectin
- Induces epithelial-mesenchymal transition (EMT) in HK-2 cells
- Associated with increased serum creatinine and urea levels
- May cause kidney injury and fibrosis
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