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Cayman Chemical 1-MSHhumnmouseratbo 10mg
Supplier: Cayman Chemical 4155410 MG
A peptide hormone; selectively binds to MC1R and MC3R over MC4R and MC5R (Kis = 0.025, 0.063, >100, and >100 µM, respectively, in insect cells expressing the human receptors) but also binds to opioid receptors in rat brain tissue homogenates (IC50 = 5.9 µM); inhibits FMRF-amide-induced contractions in isolated M. edulis catch muscle at 10 µM; intracisternal administration increases the latency to tail flick in the tail-flick test and inhibits haloperidol-induced catalepsy in mice at 0.3 nmol/animal; inhibits LPS-induced nitric oxide (NO) release in mouse forebrain in vivo at 0.01 nmol/animal
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