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Medchemexpress LLC 10,32,45,46-tetraoxatricyclo[39.3.1.119,23]hexatetraconta-5,7,21,27,29,43-hexaene-9,31-dione... | 95927-67-6 | 98.3% | 1389.87 | 10 MG
SDP

Catalog No. 5000343645
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Swinholide A is an actin-binding marine polyketide that dimerizes actin with a Kd of approximately 50 nM. It is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. It disrupts the actin cytoskeleton of cells and exhibits antifungal activity. Originally isolated from the Okinawan marine sponge *Theonella swinhoei*, Swinholide A is highly cytotoxic to various cancer cell lines. It sequesters actin dimers *in vitro* and rapidly severs F-actin *in vitro* with high cooperativity.

  • Acts as an actin-binding marine polyketide, dimerizing actin with a Kd of ~50 nM.
  • Functions as a microfilament disrupting marine toxin, stabilizing actin dimers and severing actin filaments.
  • Disrupts the actin cytoskeleton of cells.
  • Exhibits antifungal activity.
  • Highly cytotoxic against various cancer cell lines.
  • Appears as a colorless to light yellow liquid.

Catalog No. 50-003-43645 Supplier Medchemexpress LLC Supplier No. HY11100910UG
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Swinholide A is an actin-binding marine polyketide that dimerizes actin with a Kd of approximately 50 nM. It is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. It disrupts the actin cytoskeleton of cells and exhibits antifungal activity. Originally isolated from the Okinawan marine sponge *Theonella swinhoei*, Swinholide A is highly cytotoxic to various cancer cell lines. It sequesters actin dimers *in vitro* and rapidly severs F-actin *in vitro* with high cooperativity.

  • Acts as an actin-binding marine polyketide, dimerizing actin with a Kd of ~50 nM.
  • Functions as a microfilament disrupting marine toxin, stabilizing actin dimers and severing actin filaments.
  • Disrupts the actin cytoskeleton of cells.
  • Exhibits antifungal activity.
  • Highly cytotoxic against various cancer cell lines.
  • Appears as a colorless to light yellow liquid.

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