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Medchemexpress LLC 14-Deoxy-11,12-didehydroandrographolide | 42895-58-9 | 332.43 | 50 MG
Supplier: Medchemexpress LLC HYN149050MG
14-Deoxy-11,12-didehydroandrographolide is a noncytotoxic analogue of Andrographolide, primarily known for inhibiting NF-κB activation. This compound has demonstrated efficacy in a mouse asthma model, where it effectively reduces inflammatory cell recruitment, cytokine production (IL-4, IL-5, IL-13), serum IgE synthesis, pulmonary eosinophilia, mucus hypersecretion, mast cell degranulation, and airway hyper-responsiveness.
- Inhibits NF-κB activation
- Reduces inflammatory cell recruitment into bronchoalveolar lavage fluid
- Decreases IL-4, IL-5, IL-13, and eotaxin production
- Suppresses serum IgE synthesis
- Mitigates pulmonary eosinophilia and mucus hypersecretion
- Prevents mast cell degranulation
- Alleviates airway hyper-responsiveness in asthma models
- Reduces resistance and restores Cdyn in OVA-challenged mice
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