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Medchemexpress LLC 14-Deoxy-11,12-didehydroandrographolide | 42895-58-9 | 332.43 | 50 MG
SDP

Catalog No. 5000415380
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14-Deoxy-11,12-didehydroandrographolide is a noncytotoxic analogue of Andrographolide, primarily known for inhibiting NF-κB activation. This compound has demonstrated efficacy in a mouse asthma model, where it effectively reduces inflammatory cell recruitment, cytokine production (IL-4, IL-5, IL-13), serum IgE synthesis, pulmonary eosinophilia, mucus hypersecretion, mast cell degranulation, and airway hyper-responsiveness.

  • Inhibits NF-κB activation
  • Reduces inflammatory cell recruitment into bronchoalveolar lavage fluid
  • Decreases IL-4, IL-5, IL-13, and eotaxin production
  • Suppresses serum IgE synthesis
  • Mitigates pulmonary eosinophilia and mucus hypersecretion
  • Prevents mast cell degranulation
  • Alleviates airway hyper-responsiveness in asthma models
  • Reduces resistance and restores Cdyn in OVA-challenged mice

Catalog No. 50-004-15380 Supplier Medchemexpress LLC Supplier No. HYN149050MG
May include imposed supplier surcharges.
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14-Deoxy-11,12-didehydroandrographolide is a noncytotoxic analogue of Andrographolide, primarily known for inhibiting NF-κB activation. This compound has demonstrated efficacy in a mouse asthma model, where it effectively reduces inflammatory cell recruitment, cytokine production (IL-4, IL-5, IL-13), serum IgE synthesis, pulmonary eosinophilia, mucus hypersecretion, mast cell degranulation, and airway hyper-responsiveness.

  • Inhibits NF-κB activation
  • Reduces inflammatory cell recruitment into bronchoalveolar lavage fluid
  • Decreases IL-4, IL-5, IL-13, and eotaxin production
  • Suppresses serum IgE synthesis
  • Mitigates pulmonary eosinophilia and mucus hypersecretion
  • Prevents mast cell degranulation
  • Alleviates airway hyper-responsiveness in asthma models
  • Reduces resistance and restores Cdyn in OVA-challenged mice

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