Cayman Chemical 14-DeoxyndrographolIde 10mg

Supplier:  Cayman Chemical 3114010 MG

A diterpene lactone with diverse biological properties; inhibits the growth of HL-60 cells (GI50 = 25.46 µM); cytotoxic to T47D cells (EC50 = 2.8 UG/ml); increases AMPK phosphorylation and glucose uptake in L6 myotubes and potentiates the effect of insulin to increase cell surface levels of GLUT4 in L6-GLUT4myc cells at 10 and 25 µM; reduces blood glucose levels in rats in a model of streptozotocin-induced diabetes and in db/db diabetic mice at 100 mg/kg; reduces ethanol-induced hepatotoxicity in rats at 15 mg/kg per day for the last four weeks of an eight-week ethanol exposure period; reduces protein carbonyl and TBARS levels and increases GSH levels in isolated rat hepatocytes in the same model

Catalog No. 50-298-9445