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Enzo Life Sciences 17-AAG (1mg). CAS: 75747-14-7
Supplier: Enzo Life Sciences BMLEI3080001
17-AAG is a less toxic and more stable analog of geldanamycin. It is an HSP90 inhibitor that displays a 100-fold higher affinity for HSP90 derived from tumor cells compared to HSP90 from normal cells. 17-AAG inhibits Akt activation and expression in tumors and synergizes with a number of antitumor agents such as taxol, cisplatin, and UCN-014. 17-AAG causes the inactivation, destabilization and eventual degradation of HIF-1α. Inhibitor of telomerase activity. Inducer of apoptosis with antitumor activity. Inducer of macroautophagy. Alternative name: 17-(Allylamino)-17-desmethoxygeldanamycin. Purity: ≥98% (TLC). Solubility: Soluble in DMSO (>20mg/ml) or 100% ethanol (10mg/ml). Long Term Storage: -20°C.
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