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Cayman Chemical 17-EstradIol-d3 25mg
Supplier: Cayman Chemical 3897425 MG
An inhibitor of SARS-CoV-2 Mpro (Ki 3.11 nM) inhibits Mpro from SARS-CoV-1 HKU1-CoV OC43-CoV and MERS-CoV (Kis 4.94 189 36.4 and 187 nM respectively) as well as Mpro from NL-63-CoV and 229E CoV (Kis 226 and 44.4 nM respectively) selective for these enzymes over several other proteases including human and HIV-1 proteases (IC50s 100 UM for all) as well as a panel of G protein-coupled receptors kinases and transporters (IC50s ≥100 UM for all) inhibits SARS-CoV-2 replication in A549 cells (EC50 77.9 nM) and reduces the cytopathic effect of SARS-CoV-2 in infected Vero E6 cells (EC50 74.5 nM) reduces lung viral titers and the severity of pulmonary lesions in mice infected with the mouse-adapted SARS-CoV-2 MA10 variant at 300 and 1000 mg/kg
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