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Cayman Chemical 17 RRSolvIn D1 methyl Ste
Supplier: Cayman Chemical 9001072100 UG
A negative allosteric modulator and inverse agonist of mGluR5 selectively binds to mGluR5 (Ki 0.67 nM) over a panel of 63 additional receptors and ion channels at 100 nM reduces 1-IP1 accumulation a marker of 145-IP3 production in an ELISA-based immunocompetitive assay using HEK293A cells expressing rat mGluR5 (IC50 2.4 nM) increases the number of transitions between the light and dark area in a light-dark exploration test indicating anxiolytic-like activity and increases locomotor activity in the open field test in mice at 0.3 mg/kg inhibits cocaine self-administration in rats 3 or 10 mg/kg
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