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Medchemexpress LLC 17a-Hydroxypregnenolone (17-OHP5) | 387-79-1 | 99.61% | 332.48 | 100 MG
Supplier: Medchemexpress LLC HY113263100MG
17a-Hydroxypregnenolone (17-OHP5) is a metabolite of Pregnenolone and a precursor in the biosynthesis of Dehydroepiandrosterone. It acts as a substrate for the enzyme 3β-hydroxysteroid dehydrogenase (3β-HSD). This compound is formed from pregnenolone by cytochrome P450 (CYP) isoform CYP17A1 hydroxylase activity and subsequently converted to dehydroepiandrosterone by CYP17A1-mediated 17,20-lyase activity. Levels of 17a-hydroxypregnenolone are elevated in patients with type II 3β-hydroxysteroid dehydrogenase deficiency, which is a form of congenital adrenal hyperplasia.
- Metabolite of pregnenolone
- Precursor in dehydroepiandrosterone biosynthesis
- Substrate for 3β-hydroxysteroid dehydrogenase
- Formed by CYP17A1 hydroxylase activity
- Converted to dehydroepiandrosterone by CYP17A1-mediated 17,20-lyase activity
- Elevated in type II 3β-hydroxysteroid dehydrogenase deficiency
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