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Cayman Chemical 1D-ArabInofurnosyluracIl 5g
SDP

Supplier:  Cayman Chemical 298755 G

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A selective inhibitor of human FLAP (IC50 2 9 nM) selective for FLAP over 5- 12- and 15-lipoxygenase LTA4 hydrolase LTC4 synthase COX-1 and COX-2 (IC50s 10 Um for all) inhibits production of LTB4 induced by the calcium ionophore A23187 in isolated whole blood from human rat and mouse (IC50s 436 223 and 148 nM respectively) decreases increases in the levels of CysLT and LTB4 induced by lung instillation of A23187 in the BALF of rats at 1 or 3 mg/kg reduces increases in the levels of CysLT LTB4 MPO and plasma protein extravasation in a mouse model of peritonitis induced by zymosan at 3 mg/kg

Catalog No. 50-299-0258


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