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Medchemexpress LLC (1E)-CFI-400437 dihydrochloride | 1247000-76-5 | 98.0% | 565.49 | 5 MG
Supplier: Medchemexpress LLC 5MGHY132135
(1E)-CFI-400437 dihydrochloride is a potent PLK4 inhibitor with high selectivity. It also inhibits Aurora A, Aurora B, KDR, and FLT-3, demonstrating antiproliferative activity. This compound has shown effectiveness in a mouse xenograft model of tumor growth.
- Potent PLK4 inhibitor with IC50 of 0.6 nM
- Selective against other PLK family members
- Inhibits Aurora A, Aurora B, KDR, and FLT-3
- Exhibits antiproliferative activity
- Effective in mouse xenograft models of tumor growth
- Plasma protein binding is 99%
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