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Medchemexpress LLC 1H-Benzimidazole-5-carboxamide, 1-[(2E)-4-[5-(aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)ca... | 2138299-33-7 | 99.9% | 849.94 | 50 MG
Supplier: Medchemexpress LLC HY112921A50MG
diABZI STING agonist-1 tautomerism is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. It is a tautomerism of diABZI STING agonist-1.
- Selective stimulator of interferon genes (STING) receptor agonist
- EC50s of 130 nM for human and 186 nM for mouse
- Shows high selectivity against over 350 kinases tested at 1 μM
- Induces STING-dependent activation of type-I interferon and pro-inflammatory cytokines in vivo
- Exhibits systemic exposure with a half-life of 1.4 h in vivo
- Results in significant tumor growth inhibition and improved survival in vivo
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