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Medchemexpress LLC 1H-Indole-6-carboxamide, 1-[(2-chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]- | 2259624-71-8 | 98.3% | 490.88 | 100 MG
SDP

Catalog No. 5000363645
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STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC50 of 185 nM. It exhibits excellent pan-polymorph activity across a panel of STING proteins in HEK293T cells, specifically 92%, 107%, and 92% against R232, H232, and HAQ, respectively. Notably, it is not active at mouse STING. In vivo, the compound is well-absorbed with a short terminal half-life.

  • Potent, orally active human STING activator
  • Shows excellent pan-polymorph activity across STING proteins in HEK293T cells
  • Not active at mouse STING
  • Well-absorbed with a short terminal half-life in vivo

Catalog No. 50-003-63645 Supplier Medchemexpress LLC Supplier No. HY147010100MG
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STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC50 of 185 nM. It exhibits excellent pan-polymorph activity across a panel of STING proteins in HEK293T cells, specifically 92%, 107%, and 92% against R232, H232, and HAQ, respectively. Notably, it is not active at mouse STING. In vivo, the compound is well-absorbed with a short terminal half-life.

  • Potent, orally active human STING activator
  • Shows excellent pan-polymorph activity across STING proteins in HEK293T cells
  • Not active at mouse STING
  • Well-absorbed with a short terminal half-life in vivo

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