Medchemexpress LLC 1H-Isoindole-1,3(2H)-dione, 4-[(6-azidohexyl)oxy]-2-(2,6-dioxo-3-piperidinyl)- | 2411389-65-4 | 99.10% | 399.40 | 25 MG

Supplier:  Medchemexpress LLC 25MGHY148556

Thalidomide-O-C6-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates a Thalidomide-based cereblon ligand and a linker used in PROTAC technology. It functions as a click chemistry reagent, containing an Azide group, which allows it to undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules that have Alkyne groups. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

• Synthesized E3 ligase ligand-linker conjugate
• Incorporates a cereblon ligand
• Functions as a click chemistry reagent
• Contains an azide group
• Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
• Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
• Exploits intracellular ubiquitin-proteasome system for selective target protein degradation

Catalog No. 50-003-63444