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Medchemexpress LLC 1H-Pyrrole-2-carboxamide, N-(3-cyano-4-fluorophenyl)-1-methyl-4-[[[(1S)-2,2,2-trifluoro-1-methylethyl]amino]sulfonyl]- | 1638266-40-6 | 98.9% | 418.37 | 250 MG
SDP

Supplier:  Medchemexpress LLC 250MGHY109168

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Bersacapavir is an HBV capsid assembly modulator that exerts a dual mechanism of action against both early and late stages of HBV infection. It forms complete genome-free empty capsids and inhibits de novo synthesis of cccDNA, making it useful in hepatitis B research.

  • Enhances the rate and extent of HBV capsid assembly.
  • Potently inhibits HBV replication in HepG2.117 and HepG2.2.15 cells.
  • Exhibits additive to synergistic antiviral activity when combined with TDF or ETV.
  • Reduces extracellular HBV DNA, intracellular HBV RNA, extracellular HBe/cAg, and extracellular HBsAg.
  • Inhibits cccDNA formation when added to HBV-infected PHHs.
  • Disrupts pre-formed mature HBV capsids.
  • Can be dissolved in 10% DMSO and 90% corn oil for in vivo dissolution.

Catalog No. 50-003-47588


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