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Medchemexpress LLC 1H-Pyrrole-3-carboxamide, N-[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoin | 2222635-92-7 | 99.3% | 654.69 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY136688100MG

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MI-389 is a PROTAC translation termination factor GSPT1 degrader. It disrupts a target that is a shared dependency in different AML and ALL cell lines, and its action is dependent on the CRL4CRBN E3 ligase.

  • Disrupts GSPT1 target
  • Action dependent on CRL4CRBN E3 ligase
  • Target is Cereblon
  • EC50 value of 21.3 nM on Kasumi 1 cells
  • Antiproliferative activity against human Kasumi 1 cells
  • Molecular formula: C35H35FN6O6
  • Appearance: Yellow to orange solid
  • Purity: 99.34%
  • Solubility: 66.67 mg/mL (101.83 mM) in DMSO
  • Storage: 4°C, stored under nitrogen
  • In solvent storage: -80°C for 6 months; -20°C for 1 month (stored under nitrogen)

Catalog No. 50-003-52358


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