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Medchemexpress LLC (1S,2R)-Alicapistat | 2221010-57-5 | 98.0% | 433.50 | 1 ML
Supplier: Medchemexpress LLC HY109001A1MG
(1S,2R)-Alicapistat is an orally active, selective inhibitor of human calpains 1 and 2, showing potential for Alzheimer's disease treatment. It mitigates metabolic liability of carbonyl reduction and inhibits calpain 1 with an IC50 value of 395 nM.
- Orally active selective inhibitor of human calpains 1 and 2
- Potential application for Alzheimer's disease
- Mitigates metabolic liability of carbonyl reduction
- Inhibits calpain 1 with an IC50 value of 395 nM
- Prevents Aβ oligomer-induced deficits in synaptic transmission
- Displays efficacy in preventing NMDA-induced neurodegeneration and A-induced synaptic dysfunction
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