Cayman Chemical 1S 3R-RSL3 10mg

Supplier:  Cayman Chemical 1928810 MG

A ferroptosis inducer; inhibits GPX4 in a context-dependent manner; inhibits GPX4 in the presence of cell cytosol or recombinant human 14-3-3ε but does not inhibit recombinant human selenocysteine-containing GPX4 or purified rat testis GPX4, at 100 µM; inhibits peroxidase activity in GPX4-overexpressing COH-BR1 breast cancer cell lysates at 50 nM; inhibits TrxR1 (IC50 = 7.9 µM in a cell-free assay); selectively cytotoxic to H-RasV12-expressing BJeLR cells over wild-type Ras-expressing BJeH cells (EC50s = 0.01 and 2 µM, respectively); induces lipid peroxidation in Pfa1 fibroblasts at 100 nM; prevents tumor formation and inhibits tumor growth in BJeLR mouse xenograft models at 100 mg/kg

Catalog No. 50-298-5151