2,2,2-Trifluoroacetamide, 97%

Description

CAS: 354-38-1 | C2H2F3NO | 113.04 g/mol

2,2,2-Trifluoroacetamide used in a convenient alternative to the Gabriel synthesis of primary amines from halides by N-alkylation followed by cleavage of the readily-hydrolyzed trifluoroacetyl group and for improved N-alkylation under phase-transfer conditions allowing successive alkylation with different alkyl groups.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
2,2,2-Trifluoroacetamide used in a convenient alternative to the Gabriel synthesis of primary amines from halides by N-alkylation followed by cleavage of the readily-hydrolyzed trifluoroacetyl group and for improved N-alkylation under phase-transfer conditions allowing successive alkylation with different alkyl groups.

Solubility
Soluble in water (460 g/L at 20°C), alcohol, ether, chloroform (partially), and methanol.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents, strong acids, strong bases and strong reducing agents.

Specifications

Chemical Identifiers

• CAS: 354-38-1
• Molecular Formula: C2H2F3NO
• Molecular Weight (g/mol): 113.04
• MDL Number: MFCD00008008
• InChI Key: NRKYWOKHZRQRJR-UHFFFAOYSA-N
• Synonym: trifluoroacetamide, acetamide, 2,2,2-trifluoro, unii-36mu16byfk, n-trifluoroacetamide, 2,2,2-trifluoro-acetamide, 36mu16byfk, trifluroacetamide, trifluoro-acetamide, snylgqhjptadtaetp@, pubchem12622
• PubChem CID: 67717
• IUPAC Name: 2,2,2-trifluoroacetamide
• SMILES: NC(=O)C(F)(F)F

• Melting Point: 70°C to 75°C
• Boiling Point: 162°C to 164°C
• Quantity: 500 g
• Beilstein: 1753625
• Solubility Information: Soluble in water (460g/L at 20°C),alcohol,ether,chloroform (partially),and methanol.
• Formula Weight: 113.04
• Percent Purity: 97%
• Chemical Name or Material: 2,2,2-Trifluoroacetamide

Safety and Handling

Hazard Category	H315-H319-H335
Hazard Statement	GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
EINECSNumber	206-559-9
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only