2,2,6,6-Tetramethylpiperidine, 98+%, Thermo Scientific Chemicals

Description

2,2,6,6-Tetramethylpiperidine is a hindered base used to prepare metallo-amide bases and selective generation of silylketene acetals. It is used in the preparation of hibarimicinone, (Z)-silylketene acetal and 4-substituted quinazoline. It acts as a precursor to Lithium tetramethylpiperidide and (2,2,6,6-Tetramethylpiperidin-1-yl)oxyl radical.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
2,2,6,6-Tetramethylpiperidine is a hindered base used to prepare metallo-amide bases and selective generation of silylketene acetals. It is used in the preparation of hibarimicinone, (Z)-silylketene acetal and 4-substituted quinazoline. It acts as a precursor to Lithium tetramethylpiperidide and (2,2,6,6-Tetramethylpiperidin-1-yl)oxyl radical.

Solubility
Miscible with water, ether, ethanol and acetic acid. Slightly miscible with chloroform.

Notes
Incompatible with oxidizing agents, bases, strong acids, acid anhydrides, carbon dioxide and acid chlorides.

Specifications

Chemical Identifiers

• CAS: 768-66-1
• Molecular Formula: C9H19N
• Molecular Weight (g/mol): 141.258
• MDL Number: MFCD00005985
• InChI Key: RKMGAJGJIURJSJ-UHFFFAOYSA-N
• Synonym: norpempidine, piperidine, 2,2,6,6-tetramethyl, 2,2,6,6-tetramethyl piperidine, unii-44n9s1ycfm, 2,2,6,6-tetramethylpeperidine, 44n9s1ycfm, 2,2,6,6 tetramethyl piperidine, 2,2,6,6-tetramethyl-piperidine, pubchem7259, acmc-209p6i
• PubChem CID: 13035
• IUPAC Name: 2,2,6,6-tetramethylpiperidine
• SMILES: CC1(CCCC(N1)(C)C)C

• Melting Point: -59°C
• Density: 0.832
• Boiling Point: 152°C to 154°C
• Flash Point: 34°C (93°F)
• Odor: Amine-like
• Refractive Index: 1.444
• Quantity: 100 g
• UN Number: UN2733
• Beilstein: 103296
• Sensitivity: Air Sensitive
• Solubility Information: Miscible with water,ether,ethanol and acetic acid. Slightly miscible with chloroform.
• Formula Weight: 141.26
• Percent Purity: ≥98%
• Chemical Name or Material: 2,2,6,6-Tetramethylpiperidine

Safety and Handling

Hazard Category	H226-H301-H315-H319-H335
Hazard Statement	GHS H Statement H314-H318-H226-H302 Causes severe skin burns and eye damage. Causes serious eye damage. Flammable liquid and vapour. Harmful if swallowed.
Precautionary Statement	P210-P233-P235-P240-P241-P242-P243-P261-P264b-P270-P271-P280-P301+P310-P303+P361+P353-P304+P340-P305+P351+P338-P312-P330-P332+P313-P363-P370+P378q-P501c
DOTInformation	Transport Hazard Class: 3; Packing Group: III; Proper Shipping Name: AMINES, FLAMMABLE, CORROSIVE, N.O.S.
EINECSNumber	212-199-3
RTECSNumber	TN4220000
TSCA	Yes
Recommended Storage	Ambient temperatures; Store under Nitrogen

SDS

RUO – Research Use Only