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Medchemexpress LLC 2-(2,6-dioxopiperidin-3-yl)-4,5-difluoroisoindoline-1,3-dione | 2222115-19-5 | >98.0% | 294.21 g·mol⁻¹ | C13H8F2N2O4 | 50 MG
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Supplier:  Medchemexpress LLC HYW57686850MG

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Thalidomide-4,5-F is a fluorinated analogue of thalidomide that serves as a cereblon (CRBN) ligand for E3 ligase recruitment and targeted protein degradation research. It promotes ubiquitinylation of proteins and is suitable for derivatization at its fluorine positions, making it a useful building block in PROTAC and molecular glue chemistries.

  • Promotes ubiquitinylation of proteins.
  • Useful as a cereblon ligand for E3 ligase recruitment and PROTAC synthesis.
  • Fluorine positions amenable to further derivatization.
  • High purity (>98.0%).
  • Chemical formula C13H8F2N2O4; molecular weight 294.21 g·mol⁻¹.
  • Appearance: white to off-white solid; available in multiple sizes.

Catalog No. 50-002-84614


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