Medchemexpress LLC 2-[(2-chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)indazole | 875787-07-8 | MFCD16495812 | 100.0% | 422.78 | C21H12ClF5N2 | 10 MG

Supplier:  Medchemexpress LLC HY1062910MG

LXR-623 is a brain-penetrant liver X receptor modulator that acts as a partial agonist at LXRα and a full agonist at LXRβ, with reported IC50s of 24 nM and 179 nM, respectively. It is orally bioavailable and has been used in preclinical studies to induce target gene expression, modulate lipid-related proteins, and produce antitumor activity in glioblastoma and atherosclerosis models.

• Brain-penetrant compound suitable for CNS research.
• Selective activity on LXRα (partial) and LXRβ (full) with low-nanomolar potency.
• Orally bioavailable and demonstrated to cross the blood-brain barrier.
• Induces ABCA1 and ABCG1 transcription and modulates LDLR protein levels.
• Shown to induce tumor cell death and extend survival in preclinical glioblastoma models.
• High-purity solid with established solubility protocols for in vitro and in vivo use.

Catalog No. 50-002-42899