Medchemexpress LLC 2-[(2-chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)indazole | 875787-07-8 | MFCD16495812 | 100.0% | 422.78 g·mol⁻1 | C21H12ClF5N2 | 1 ML

Supplier:  Medchemexpress LLC HY1062910MM 1ML

LXR-623 is a brain-penetrant liver X receptor modulator that acts as a partial agonist at LXRα and a full agonist at LXRβ. It exhibits IC50 values of 24 nM for LXRα and 179 nM for LXRβ and is used in both in vitro and in vivo research to modulate cholesterol metabolism, induce ABCA1 expression, suppress LDLR, and reduce tumor progression in glioblastoma models.

• Brain-penetrant, crosses the blood-brain barrier.
• Selective LXR modulation: partial agonist at LXRα and full agonist at LXRβ.
• Potent activity with IC50s of 24 nM (LXRα) and 179 nM (LXRβ).
• Demonstrated efficacy in glioblastoma and atherosclerosis models.
• High purity suitable for research applications.
• Soluble in DMSO for in vitro use and formulating for in vivo dosing.

Catalog No. 50-002-42250