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Medchemexpress LLC 2-(2-chlorophenyl)-2-(5,7-dichloro-3-(hydroxymethyl)-4,6-dimethyl-1H-indol-2-yl)-N-((4-methylphenyl)su | 2244452-09-1 | 99.6% | 499.36 g/mol | C21H20Cl2N2O6S | 1MG
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Supplier:  Medchemexpress LLC HY1262541MG

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BI-4924 is a potent, selective small-molecule inhibitor of phosphoglycerate dehydrogenase (PHGDH) used in biochemical and cellular research to probe serine biosynthesis and PHGDH-dependent metabolism. The compound is a hydroxymethylene-bearing carboxylic acid derivative (CAS 2244452-09-1) with characterized physicochemical and solubility properties.

  • Potent PHGDH inhibition: IC50 = 3 nM.
  • Disrupts serine biosynthesis in cells (IC50 ≈ 2.2 μM at 72 h).
  • Chemical formula C21H20Cl2N2O6S; molecular weight 499.36 g/mol.
  • High purity: 99.6% (reported by supplier).
  • Form: powder; suitable for DMSO stock solutions.
  • Solubility in vitro: DMSO 125 mg/mL (≈250 mM; ultrasonic recommended).
  • In vivo formulations documented for multiple vehicles at ≥2.08 mg/mL.

Catalog No. 50-002-36658


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