2,2-Difluoroacetophenone, 95%

Catalog No.	Quantity
AAH25750MD	250 mg
AAH2575003	1 g
AAH2575006	5 g

Catalog No. AAH25750MD Supplier Thermo Scientific Chemicals Supplier No. H25750MD

Description

CAS: 395-01-7 | C8H6F2O | 156.132 g/mol

2,2-Difluoroacetophenone acts as an intermediate in the preparation of various substances such as pharmaceuticals. Further, it is used in the one-pot synthesis of difluoromethylated arenes from aryl chlorides and bromides. In addition to this, it undergoes reduction with (-)-diisopinocampheylchloroborane chloride to get R-alcohols of purity 85% ee.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
2,2-Difluoroacetophenone acts as an intermediate in the preparation of various substances such as pharmaceuticals. Further, it is used in the one-pot synthesis of difluoromethylated arenes from aryl chlorides and bromides. In addition to this, it undergoes reduction with (-)-diisopinocampheylchloroborane chloride to get R-alcohols of purity 85% ee.

Solubility
Immiscible with water.

Notes
Incompatible with strong oxidizing agents and strong acids.

Specifications

Chemical Identifiers

• CAS: 395-01-7
• Molecular Formula: C8H6F2O
• Molecular Weight (g/mol): 156.132
• MDL Number: MFCD06246879
• InChI Key: OLYKCPDTXVZOQF-UHFFFAOYSA-N
• Synonym: 2,2-difluoroacetophenone, alpha,alpha-difluoroacetophenone, 2,2-difluoro-1-phenyl-ethanone, 2,2-difluoro-1-phenylethan-1-one, a,a-difluoroacetophenone, ethanone, 2,2-difluoro-1-phenyl, difluoromethyl phenyl ketone, difluoroacetophenone, acmc-20aojw, acetophenone, 2,2-difluoro
• PubChem CID: 273286
• IUPAC Name: 2,2-difluoro-1-phenylethanone
• SMILES: C1=CC=C(C=C1)C(=O)C(F)F

• Melting Point: 48°C to 50°C
• Boiling Point: 53°C to 54°C (12 mmHg)
• Odor: Characteristic
• Refractive Index: 1.4955
• Quantity: 250 mg
• Solubility Information: Immiscible with water.
• Formula Weight: 156.13
• Percent Purity: 95%
• Chemical Name or Material: 2,2-Difluoroacetophenone

Safety and Handling

Hazard Category	H315-H319-H335
Hazard Statement	GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only