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Apexbio Technology LLC 2'3'-cGAMP (sodium salt), 1mg CAS# 1441190-66-4
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Supplier:  Apexbio Technology LLC B83621

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2,3-cGAMP (sodium salt) is a second messenger generated by the enzyme cGAMP synthase (cGAS) in the cytoplasm of mammalian cells, in response to the presence of double-stranded DNA. As a second messenger, 2,3-cGAMP sodium salt activates innate immune responses via binding of STING (stimulator of IFN genes) and initiates the TBK1-IRF3-dependent production of IFN-. It is used to identify small compounds that bind to STING. It is also applicable in the research of type I interferon response to cytosolic DNA. The binding affinity of 2,3-cGAMP to STING is 3.79 nM (Kd value), which is stronger than other cyclic di-nucleotides, e.g. cyclic di-GMP, 32-cGAMP, 33-cGAMP and 22-cGAMP (Kds = 1.21 M, 1.61 M, 1.04 M and 287 nM, respectively). Other sizes are also available. Please inqury us for quote.

Catalog No. 50-199-8416


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