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Cayman Chemical 2 3-IsopropylIden-D-rIbonla 1g
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Supplier:  Cayman Chemical 304791 G

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An Aurora kinase inhibitor inhibits Aurora A and B by 82 and 60 respectively at 1 M in cell free assays selective for Aurora A and B over a panel of 13 kinases at 1 M inhibits growth of various cancer cell lines (GI50s 0 08-1 2 M) induces DNA accumulation and cell cycle arrest at the G2/M phase as well as apoptosis in HCT116 cells increases the accumulation of doxorubicin and rhodamine 123 in MDR KBv200 and MCF-7/adr cells and increases the susceptibility of MDR KBv200 MCF-7/adr S1-M1-80 and HL60/adr cells to cisplatin and doxorubicin reduces tumor growth in an HCT116 mouse xenograft model at 100 mg/kg potentiates the antitumor effects of vincristine in a KBv200 mouse xenograft model

Catalog No. 50-299-2628


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