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Sigma Aldrich 2-(3-(Piperidin-4-Yl)Phenyl)Ethan-1-Amine Dihydrochloride

Catalog No. 916641100MG Shop All MilliporeSigma Sigma Organic Chemistry Products
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91-664-1100MG 100 mg
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Description

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

2-(3-(Piperidin-4-yl)phenyl)ethan-1-amine dihydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.Crosslinkers for BioconjugationTechnology Spotlight: Degrader Building Blocks for Targeted Protein DegradationPortal: Building PROTAC™ Degraders for Targeted Protein DegradationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Specifications

Molecular Formula C38H51ClN2O10
Linear Formula C38H51ClN2O10
Quantity 100 mg
Synonym (S)-1-((S)-2-((S)-2-Aminopropanamido)-2-cyclohexylacetyl)-N-((S)-1-(ethylamino)-3-(4-fluorophenyl)-1-oxopropan-2-yl)pyrrolidine-2-carboxamide; AVP ligand; IAP E3 ligase lead for protein degrader research; SNIPER building block
Molecular Weight (g/mol) 517.64 g/mol
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