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Medchemexpress LLC 2,4(1H,3H)-Pyrimidinedione, 6-(octylamino)- | 83797-69-7 | 99.8% | 50 MG
SDP

Catalog No. 5000341691
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6-OAU (6-n-octylaminouracil) is a GPR84 (G protein-coupled receptor 84) agonist with an EC50 value of 105 nM. It acts as a chemoattractant for both polymorphonuclear leukocytes (PMNs) and macrophages, amplifying the proinflammatory cytokine IL-8 and demonstrating proinflammatory activity. This compound also exhibits anti-bacterial functions.

  • Activates GPR84 with an EC50 of 105 nM in HEK293 cells.
  • Promotes PMN chemotaxis with an EC50 of 318 nM.
  • Increases IL-8 secretion from LPS-stimulated PMNs.
  • Amplifies TNF-α production from U937 macrophages.
  • Reduces ROS production during *B. abortus* infection.
  • Inhibits adhesion and *Brucella* uptake.
  • Displays anti-infection against *Brucella* and *Salmonella*.
  • Activates GPR84 leading to inflammatory conditions *in vivo*.
  • Augments resistance to *Brucella* infection and reduces bacterial proliferation *in vivo*.

Catalog No. 50-003-41691 Supplier Medchemexpress LLC Supplier No. HY1276450MG
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6-OAU (6-n-octylaminouracil) is a GPR84 (G protein-coupled receptor 84) agonist with an EC50 value of 105 nM. It acts as a chemoattractant for both polymorphonuclear leukocytes (PMNs) and macrophages, amplifying the proinflammatory cytokine IL-8 and demonstrating proinflammatory activity. This compound also exhibits anti-bacterial functions.

  • Activates GPR84 with an EC50 of 105 nM in HEK293 cells.
  • Promotes PMN chemotaxis with an EC50 of 318 nM.
  • Increases IL-8 secretion from LPS-stimulated PMNs.
  • Amplifies TNF-α production from U937 macrophages.
  • Reduces ROS production during *B. abortus* infection.
  • Inhibits adhesion and *Brucella* uptake.
  • Displays anti-infection against *Brucella* and *Salmonella*.
  • Activates GPR84 leading to inflammatory conditions *in vivo*.
  • Augments resistance to *Brucella* infection and reduces bacterial proliferation *in vivo*.

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