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Medchemexpress LLC 2-[[4-(diethylamino)-2-hydroxyphenyl]methylene]hydrazide-4-pyridinecarboxylic acid | 140405-36-3 | 99.7% | 312.37 | C17H20N4O2 | 25 MG
SDP

Supplier:  Medchemexpress LLC HY10323825MG

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RSVA405 is a potent, orally active activator of AMP-activated protein kinase (AMPK) used in preclinical research. It facilitates CaMKKβ-dependent AMPK activation, inhibits mTOR, promotes autophagy and lysosomal degradation of Aβ, and exhibits anti-inflammatory effects via STAT3 inhibition. Activity is observed in vitro (EC50 ≈ 1 μM) and in vivo in metabolic and renal models.

  • Potent AMPK activator with an EC50 of approximately 1 μM.
  • Promotes autophagy and lysosomal degradation of Aβ.
  • Inhibits mTOR and modulates adipocyte differentiation.
  • Exhibits anti-inflammatory effects through STAT3 inhibition.
  • Demonstrated in vitro and in vivo activity in metabolic and renal models.
  • Supplied as a light yellow to yellow solid with high purity.

Catalog No. 50-002-47220


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