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Medchemexpress LLC 2,4-Pyrimidinediamine, N2-1H-benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)- | 1216665-49-4 | 99.9% | 332.36 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY1753750MG

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APY29 is an ATP-competitive inhibitor and an allosteric modulator of IRE1α. It inhibits IRE1α autophosphorylation by binding to its ATP-binding pocket with an IC50 of 280 nM. Additionally, APY29 functions as a ligand that allosterically activates the adjacent RNase domain of IRE1α.

  • ATP-competitive inhibitor of IRE1α
  • Allosteric modulator of IRE1α
  • Inhibits IRE1α autophosphorylation with an IC50 of 280 nM
  • Acts as a ligand that allosterically activates the IRE1α adjacent RNase domain
  • Divergently modulates the RNase activity and oligomerization state of IRE1α

Catalog No. 50-003-86254


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