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Medchemexpress LLC 2,4-Pyrimidinediamine, N4-cyclopropyl-N2-(3,4-dimethoxyphenyl)-5-(trifluoromethyl)- | 1884222-74-5 | 98.0% | 354.33 | 100 MG
Supplier: Medchemexpress LLC HY137742100MG
SBP-7455 is a potent, high-affinity, and orally active dual ULK1/ULK2 autophagy inhibitor. It exhibits IC50s of 13 nM for ULK1 and 476 nM for ULK2 in ADP-Glo assays. This compound effectively inhibits ULK1/2 enzymatic activity and is suitable for research related to triple-negative breast cancer (TNBC).
- Potent and high-affinity dual ULK1/ULK2 autophagy inhibitor
- Effectively inhibits ULK1/2 enzymatic activity
- Suitable for triple-negative breast cancer (TNBC) research
- Inhibits cell growth in MDA-MB-468 cells
- Suppresses starvation-induced autophagic flux in TNBC cells
- Oral administration demonstrates sustained plasma concentrations
- Leads to robust inhibition of pATG13 (Ser318) and downregulation of ATG13 and ULK1 levels in liver samples
- Appearance: solid, white to off-white
- Solubility: 125 mg/mL in DMSO, requires ultrasonication
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