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Medchemexpress LLC 2,5-Dihydroxyacetophenone | 490-78-8 | MFCD00002343 | 152.15 | 5 G
SDP

Catalog No. 5000447008
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2,5-Dihydroxyacetophenone, isolated from Rehmannia glutinosa, inhibits the production of inflammatory mediators in activated macrophages by blocking the ERK1/2 and NF-κB signaling pathways. It significantly inhibits NO production by suppressing iNOS expression and decreases levels of pro-inflammatory cytokines TNF-α and IL-6 via down-regulation of their mRNA expression in LPS-stimulated RAW264.7 cells. It also potently inhibits the phosphorylation of extracellular signal-related kinase (ERK) 1/2 and the nuclear translocation of nuclear factor-κB (NF-κB) p65 in LPS-stimulated cells.

  • Isolated from Rehmannia glutinosa
  • Inhibits production of inflammatory mediators
  • Blocks ERK1/2 and NF-κB signaling pathways
  • Suppresses iNOS expression
  • Decreases pro-inflammatory cytokines TNF-α and IL-6
  • Inhibits phosphorylation of ERK1/2
  • Inhibits nuclear translocation of NF-κB p65

Catalog No. 50-004-47008 Supplier Medchemexpress LLC Supplier No. HYW0011745G
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2,5-Dihydroxyacetophenone, isolated from Rehmannia glutinosa, inhibits the production of inflammatory mediators in activated macrophages by blocking the ERK1/2 and NF-κB signaling pathways. It significantly inhibits NO production by suppressing iNOS expression and decreases levels of pro-inflammatory cytokines TNF-α and IL-6 via down-regulation of their mRNA expression in LPS-stimulated RAW264.7 cells. It also potently inhibits the phosphorylation of extracellular signal-related kinase (ERK) 1/2 and the nuclear translocation of nuclear factor-κB (NF-κB) p65 in LPS-stimulated cells.

  • Isolated from Rehmannia glutinosa
  • Inhibits production of inflammatory mediators
  • Blocks ERK1/2 and NF-κB signaling pathways
  • Suppresses iNOS expression
  • Decreases pro-inflammatory cytokines TNF-α and IL-6
  • Inhibits phosphorylation of ERK1/2
  • Inhibits nuclear translocation of NF-κB p65

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