Medchemexpress LLC 2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide | 1258292-64-6 | 99.8% | 1 ML

Supplier:  Medchemexpress LLC HY12046910MM 1ML

GDC-046 (2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide) is a potent, selective, orally bioavailable TYK2 inhibitor with reported Ki values of 4.8 nM (TYK2), 0.7 nM (JAK1), 0.7 nM (JAK2), and 0.4 nM (JAK3). Supplied for research use, available as a 10 mM solution in DMSO (1 mL) or as solid material.

• Potent, selective TYK2 inhibitor with low-nanomolar activity against JAK family kinases.
• Molecular weight 350.2 g/mol; formula C16H13Cl2N3O2.
• CAS 1258292-64-6; purity 99.8%.
• Physical form solid, off-white to yellow; also supplied as 10 mM solution in DMSO (1 mL).
• Solubility in DMSO 62.5 mg/mL (178.47 mM); ultrasonic assistance recommended.
• Storage: solid at 4 °C; in solvent store at -80 °C (up to 6 months) or -20 °C (up to 1 month); protect from light.

Catalog No. 50-002-34320