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Medchemexpress LLC (2,6-dimethylpyridin-4-yl)-[4-[7-(4-hydroxycyclohexyl)-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimi | 2226789-82-6 | 99.9% | 518.69 | C30H42N6O2 | 5 MG
SDP

Supplier:  Medchemexpress LLC HY1322005MG

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UNC5293 is a potent, orally available small-molecule inhibitor selective for the MER receptor tyrosine kinase (MERTK). It demonstrates subnanomolar biochemical potency, cellular activity in B-ALL models, and favorable mouse pharmacokinetic properties; intended for research use.

  • Biochemical Ki = 190 pM and MERTK IC50 = 0.9 nM.
  • Cellular MERTK phosphorylation IC50 = 9.4 nM in B-ALL cells.
  • Selective over Axl, Tyro3, and Flt3; less potent versus FLT3 (IC50 = 170 nM).
  • Molecular weight 518.69 and formula C30H42N6O2.
  • Purity 99.93% and supplied as a 5 mg pack.
  • Exhibits favorable mouse pharmacokinetic properties and utility in leukemia research.

Catalog No. 50-002-62962


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